Vitiligo with tacrolimus two months after the itch, consider the adverse drug reaction, vitiligo progression stage, improper treatment and other factors caused. 1. Adverse drug reactions: tacrolimus instructions state that itching and other discomforts may occur within 12 weeks, so there is a possibility that the itchy skin is caused by adverse drug reactions. 2. Vitiligo progression: when vitiligo is in the progression stage, even though the medication is used, but there may still be itchy skin. 3. Improper treatment: The treatment with tacrolimus is accompanied by photosensitizers. The skin’s sensitivity to ultraviolet light increases and exposure to ultraviolet light may lead to itchy skin. 4. Contact dermatitis: if the patient is allergic, contact with tacrolimus can cause an allergic reaction, erythema, papules, with itching and other symptoms. Vitiligo patients itchy skin during treatment, it is recommended to hospital dermatology examination, looking for causes of itching skin, but also under the guidance of the doctor to give topical, if necessary, with oral medication.