Suspicion is seen clinically in a variety of disorders, such as schizophrenia, hypochondria, anxiety disorders, etc. If the patient is suspicious, paranoid and sensitive under the domination of hallucinations and delusions, once the diagnosis of schizophrenia is confirmed, the application of antipsychotic drugs, such as olanzapine, quetiapine, aripiprazole and other drugs systematically regulated treatment is needed to achieve good therapeutic results. If hypochondriasis is mainly based on doubting one’s own health condition, and has been repeatedly examined several times, and does not trust the doctor’s examination results or the doctor’s guidance, it can be considered as hypochondriasis. Psychotherapy and medication are mainly used clinically, such as the application of anti-anxiety drugs or antidepressants, which can achieve good therapeutic results. There are also some patients with anxiety disorders who are suspicious, such as worrying and doubting about the uncertainty of the future, mainly about their body, the health of their family, and all the affairs around them, accompanied by plant nerve dysfunction and fidgeting. Once diagnosed as anxiety disorder, it can be treated by applying anti-anxiety drugs, or antidepressants, such as lorazepam, alprazolam, or paroxetine, sertraline, fluoxetine, etc., with good results.