A raised hard bump on the hand itchy mainly because of nodular itchy rash, sweat pore keratosis, sweat herpes and other causes, need to be under the guidance of the doctor using physical, applying drugs, oral medication methods of treatment. 1. Nodular itchy rash: nodular itchy rash is a chronic skin disease, mainly caused by insect bites and gastrointestinal dysfunction. It can be treated with physical therapy such as laser and freezing. 2. Keratosis Pilaris: Keratosis Pilaris is mainly caused by genetic factors, and the lesions will lead to keratotic papules on the skin. It can be treated with topical mometasone furoate cream and oral medication such as hydroxychloroquine. 3. Sweat herpes: Sweat herpes is a kind of skin disease that occurs on the hands and feet, mainly caused by ultraviolet radiation, skin fungus infection, etc. The lesions will lead to skin irritation and the symptoms mentioned above. It can be treated with topical glycerite lotion, oral loratadine tablets and other medications. Patients who have a raised hard lump on their hands that itches try not to scratch the affected area, so as not to cause bacterial growth and aggravate the infection. Promptly consult a doctor to clarify the diagnosis, the above drugs should be used under the guidance of a doctor.