Envolizumab has side effects, the common ones are injection site pain, swelling, bone marrow suppression, malaise, rash, abnormal thyroid function, gastrointestinal reaction, liver toxicity. Envolizumab injection is a malignant tumor immunotherapy drug, clinically mainly used for unresectable, or metastatic microsatellite highly unstable, or mismatch repair gene defective type of adult patients with advanced solid tumors, including patients with advanced colorectal cancer with disease progression after first-line chemotherapy, and patients with other advanced solid tumors with disease progression after previous treatment and no satisfactory alternative treatment options. The common adverse reactions of Envolizumab Injection include local reaction and systemic reaction: 1. Local reactions: pain and swelling at the injection site. 2. Systemic reactions: bone marrow suppression, including reduction of white blood cells, neutrophils and red blood cells; malaise; rash; abnormal thyroid function, including hyper- or hypothyroidism; gastrointestinal reactions, such as nausea, loss of appetite, abdominal distension, etc.; hepatotoxicity, such as elevation of aminotransferases. As an antitumor drug, Envolizumab Injection requires professional medical guidance for use.