Re-metastasis of colon cancer after postoperative chemotherapy can be treated by surgery, targeted therapy, chemotherapy and radiotherapy. 1. Surgery: for patients with distant metastasis, if the situation permits, the primary tumor can be removed to reduce the tumor load, and the commonly used surgical method is palliative surgery. 2. Targeted therapy: patients should cooperate with doctors to use targeted drugs such as bevacizumab and cetuximab, which can inhibit the proliferation of tumor vascular endothelial cells and the formation of new blood vessels to a certain extent. 3. Chemotherapy: chemotherapeutic drugs such as oxaliplatin and fluorouracil can be used under the guidance of doctors. 4. Radiation therapy: this method can effectively reduce the local recurrence rate and eliminate metastatic foci of tumor, so as to improve the effect of other treatments. To sum up, patients who have metastasized again after postoperative chemotherapy for colon cancer need to actively cooperate with doctors to adjust the treatment plan, strengthen daily life management, and go to the hospital for follow-up consultation on time.