Generalized itching may be caused by urticaria, diabetes, etc. It can be treated by daily care and medication. 1. Urticaria: Avoid contact with suspected allergens, do more indoor ventilation to ensure air circulation and freshness, and dry bedding diligently. You can choose to use topical glycerine lotion, mometasone furoate cream, etc., oral loratadine tablets, cetirizine hydrochloride tablets and other drugs for treatment. 2. Diabetes: can timely improve the diet, appropriate sports, weight control. You can choose to use glibenclamide tablets, metformin hydrochloride extended-release tablets and other drugs for treatment. Generalized itching may also be caused by pruritus and other diseases, it is recommended that the hospital dermatology department, the above drugs should be used in accordance with medical advice.