In general men taking spironolactone and estrogen for three months or more may have feminized manifestations such as testicular atrophy, decreased libido, breast development, softening of sweat hair, and accumulation of subcutaneous fat. When men take spironolactone and estrogen, both cause a decrease in testosterone levels, leading to irreversible testicular degeneration. However, this requires a certain cumulative effect of doses to cause testicular degeneration. There are individual differences in how long to take the drugs due to individual tolerance, but it generally takes more than three months for feminization to manifest. When taking spironolactone, adverse reactions such as gastric ulcers and diarrhea may occur, and people with hyperkalemia are not allowed to use it, and care should be taken to prevent electrolyte disorders when using it. When using estrogen, it may cause dizziness, nausea and other adverse reactions, people with thrombophilia can not be used, use should pay attention to regular monitoring of blood pressure and liver function. It is recommended not to use the drug blindly on your own to avoid adverse reactions, when there are uncomfortable symptoms, you need to go to the hospital to consult a doctor, under the guidance of the doctor to use the drug.