Immunotherapy includes traditional immunomodulation therapy, cellular biological therapy and immune checkpoint therapy, according to the different treatment methods, the time of pregnancy should be analyzed specifically: 1.Traditional immunomodulation therapy mainly uses drugs such as interleukin 2, interferon-α, thymidine, thymopentapeptide, etc., and pregnancy can be achieved 3 months after the end of medication; 2.Cellular biological therapy means that immune cells are cultured in vitro and then transfused back into the patient, which has no major impact on fertility. It has no major impact on fertility; 3. Immune checkpoint therapy includes PD-1, PD-L1 and other drugs, which are more damaging to the body and it is recommended to prepare for pregnancy half a year after the drug is finished. Since this treatment is mostly used for advanced tumors, in addition to the influence of drugs, it should be decided according to the patient’s condition. The specific medication should be combined with clinical and guided by doctor’s interview.