There is no specific dosage for the combination of spironolactone tablets and hydrochlorothiazide tablets, the clinic will generally customize the individualized dosage plan according to the patient’s condition, and the patient needs to standardize the use of medication under the guidance of the doctor. Hydrochlorothiazide tablets are diuretics, which can lower blood pressure and have diuretic effect, often used in combination with other antihypertensive drugs. The drug is suitable for the treatment of edematous diseases such as congestive heart failure, cirrhosis ascites, nephrotic syndrome, acute and chronic nephritis edema caused by sodium and water retention, hypertension, central or renal urolithiasis, nephrolithiasis. Spironolactone tablets are potassium-preserving diuretics used for the prevention of edematous diseases, hypertension, primary aldosteronism, and hypokalemia. The diuretic effect of the drug is weak, slow and persistent, and its diuretic effect may gradually weaken after a period of continuous use. Spironolactone and hydrochlorothiazide can be used in combination, both belong to diuretics, the combination can play a synergistic diuretic effect, increase the therapeutic effect, and also can reduce the risk of hypokalemia; patients with hepatic and renal insufficiency should use with caution, and long-term use of drugs need to check the level of potassium on a regular basis. It is recommended that patients should pay attention to low-salt and low-fat diet to avoid sodium retention, and go to the hospital regularly for follow-up examination to monitor the changes of the condition.