Syphilis stage 2 symptoms are mostly characterized by damage to the skin and mucous membranes, but can also accumulate bones, eyes and the nervous system. Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete. The second stage of syphilis often occurs after 6 to 8 weeks after the appearance of the hard chancre (7 to 10 weeks of infection). This period is characterized by a syphilis rash, which generally refers to reddish-brown or reddish papules, macules, and plaques, sometimes with pustules and ulcers on the skin and mucous membranes. Flat warts may also appear, preferably on moist and friction-prone areas of the skin such as the perianal area and external genitalia, manifesting as hypertrophic plaques with a flattened and vesiculated surface. In addition, the second stage of syphilis may also appear patchy hair loss, muscle pain, arthritis, iridocyclitis, retinitis, etc., and headache, vomiting, and unresponsive and other neurological damage. There are many symptoms of syphilis stage 2, if the above symptoms, may have entered the second stage of syphilis, it is recommended to go to the hospital in a timely manner, relevant examinations and active treatment, so as not to delay the condition.