There is no absolute relationship between high blood pressure and hepatitis B vaccination, but if the patient’s blood pressure is high and his/her vital signs are not stable, it is recommended to control the blood pressure and stabilize it before injecting hepatitis B vaccine. Patients suffering from hypertension are divided into grade 1, grade 2 and grade 3 hypertension, and the treatment is as follows: 1, if the patient’s blood pressure has been in a high state, and it is difficult to reach the normal value range with antihypertensive drugs, it can not affect the injection of hepatitis B vaccine; 2, if the patient’s transient elevated blood pressure, it can be taken with nifedipine tablets under the tongue, the blood pressure can be lowered to normal very quickly, and then the injection of hepatitis B vaccine can be carried out after the stabilization of the blood pressure; 3, if for hypertension grade 3, the patient is accompanied by dizziness, headache and other symptoms at the same time, it is not recommended to inject hepatitis B vaccine, wait until the blood pressure is controlled and stabilized before injecting hepatitis B vaccine.