The causes of itchy legs at night include physiological causes such as dryness, pathological causes such as athlete’s foot, eczema, contact dermatitis, allergies, mosquito bites, etc. The treatment includes moisturizing and medication. 1. Dryness: leg itching is often caused by dry skin, need to strengthen the skin moisturizing and nourishing, if necessary, oral antihistamine drugs to stop itching. 2. Eczema: If the patient is a patient with eczema, dexamethasone cream can be given anti-inflammatory treatment. 3. Contact dermatitis: For patients with contact dermatitis, antihistamines such as loratadine can be given at this time. 4. Allergy: If the patient is allergic to the bedding and other allergies triggered by the itchy thighs, then the bedding should be replaced, and then give cetirizine and other drugs anti-allergy treatment. 5. Mosquito bites: If the patient is mosquito bites caused by itchy thighs, then you can give glycerine lotion to stop itching treatment. Finally, the symptoms of itchy legs at night, please consult a doctor in time, the above drugs need to follow the doctor’s advice.