Do you have such “empathy”? After eating chili peppers at the time is cheerful, the next day when the bowel movement is always so difficult, think “chrysanthemum on fire”, “chrysanthemum” is really flammable? And what is the “fire” ignited “chrysanthemum”? Today, I will tell you the story of pepper and anal burning. Did my “asshole” burn? Capsaicin receptors transmit a burning sensation to the brain, so when the capsaicin receptors on the anus are activated, the brain perceives a burning sensation in the anus. Most people have this sensation, but there is nothing to worry about because the anus is not really on fire, nor is it injured, and the sensation will fade away. What is “capsaicin”? Why do chili peppers bring “hot” and “cool” sensations? It is mainly due to capsaicin. Capsaicin is an alkaloid with vanilloid amide, which binds to vanilloid receptor subtype 1 of sensory neurons. Since the VR1 receptor activation is transmitted by the burning sensation. So when you eat chili peppers, what you feel is a burning sensation This burning sensation creates a false concept in the brain that the organism is injured and initially releases the body’s own pain-relieving substance, endorphins, so it can give a stimulating sensation, the more you eat, the more you want to eat. Capsaicin can have a spicy sensation in the mouth, but not when it reaches the stomach. “Is capsaicin friendly to your intestines? Many people feel something wrong in their stomachs after the thrill of eating chili peppers has passed, and soon their stomachs will hurt and scream, and then they will go to the toilet to have a “diarrhea”. There is no clear explanation for the cause of diarrhea caused by eating chili peppers, but the stimulation of colon cells by capsaicin, which leads to disorders of gastrointestinal motility, may be one of the causes. Activation of capsaicin receptors in colon cells can cause disruption of colon motility. The role of the colon is to slowly push unformed stool to the anus, absorbing the water in the process and forming the stool. Over-activation of capsaicin receptors can make the movement of the colon faster and more irregular, resulting in the intestinal tube not having enough time to absorb water, which ultimately prevents the stool from forming and naturally results in loose stools, or diarrhea. Is your “chrysanthemum” really okay? After eating so much food containing capsaicin, capsaicin will inevitably go through the long intestinal tract with the food, along with feces to the anus, after a bowel movement, some people will feel hot and spicy anus, as if burned by fire, and some vague pain. This is easily explained because capsaicin receptors transmit to the brain mainly a feeling of being burned, so when the capsaicin receptors on the anus are activated, what the brain perceives is also the feeling of the anus being on fire. This feeling, which most people have, is not something to worry about because the anus is not on fire or injured, and when the capsaicin stimulation slowly wears off, the feeling will naturally cease to exist. Of course, if you continue to eat a lot of chili peppers every day, it is not impossible to be “burned asshole” for years and years. Some people may ask, why other people eat chili peppers are fine, but they eat it and diarrhea and anal burning? I think this is probably related to the differences in the expression of capsaicin receptors in each person – people living in Hunan, Sichuan and other places, due to dietary habits, perhaps the expression of capsaicin receptors will be less, which may be one of the reasons why they are not afraid of spicy nature.