Colistin hydrochloride tablets can cause rebound increase in blood pressure if the drug is stopped suddenly, so the drug must be stopped within 1 to 2 weeks and gradually reduced, along with other antihypertensive treatment. If surgery is required and the drug must be stopped immediately, it should be stopped 4-6 hours before the operation, the antihypertensive drug should be administered intraoperatively, and the drug should be resumed after the operation. This medication is used to treat symptoms of high blood pressure, hypertensive emergencies, migraines, menopausal hot flashes, menstrual cramps, and symptoms of opioid addiction withdrawal. Adverse effects such as dry mouth, drowsiness, dizziness, depression, constipation, sedation, decreased sexual function, nocturia, itching, nausea and vomiting, insomnia, and hives may occur with the use of this medication. The use of the drug should be noted that the drug is prohibited for those who are allergic to colistin; long-term use of the drug due to fluid retention and blood volume expansion, can produce drug resistance, the antihypertensive effect is weakened; in order to ensure the control of nocturnal blood pressure, the end of the day to take the drug should be at bedtime; suffering from cerebrovascular disease, coronary artery insufficiency of blood supply, history of depression, recent myocardial infarction, Raynaud’s disease, and other patients should be careful to use the drug. The drug needs to be used under the guidance of a doctor to avoid unauthorized use.