Maxillofacial pain is one of the head and facial pain conditions, and more and more research on head and facial pain is being conducted, with the participation of neurology, pain medicine, maxillofacial surgery, and Chinese medicine, etc. Oral and maxillofacial pain is relatively common in clinical practice, and the following disorders can cause maxillofacial pain. ① dental disorders; ② temporomandibular joint disorders; ③ oral mucosal disorders, inflammation, infection; ④ oral and maxillofacial tumors; ⑤ nerve disorders (trigeminal nerve, linguopharyngeal neuropathy). I. Pain caused by dental disease: such as tooth decay, periodontal inflammation can cause jaw and face or headache, pulpitis caused by tooth decay can cause severe head and face pain, unbearable, especially pain at night, affecting sleep, and can be complicated by jaw and face inflammation, swelling, tissue gap infection, pus causing continuous pain, throbbing pain, fever, general discomfort, serious infection requires hospitalization, so tooth pain is Therefore, tooth pain is an early signal of oral diseases, and should be checked and handled early or regular oral health checkups, which is an effective measure to prevent oral diseases. Tianjin Oral Hospital Oral Surgery Department Du Xiaoming Second, the pain caused by oral mucosa diseases: such as oral lichen planus and oral ulcers can appear pain. If pain occurs, it should be examined as early as possible, so that early detection and early exclusion of oral malignant tumors. Pain caused by malignant tumor: Oral malignant tumor is mostly found in adults aged 40-60 years old, and it is usually found in tongue, cheek, gum and maxilla and mandible. As the early clinical manifestations of malignant tumors of tongue, cheek, lip and gum are similar to oral ulcers with pain, the early malignant tumors of jaw bone often show symptoms such as painful loosening of teeth and numbness of lower lip, etc. Specialist examination should be conducted as early as possible. Advanced oral cancer is often painful with persistent severe pain, and pain treatment should be performed at the same time of cancer treatment. According to NCCN clinical practice guidelines for cancer pain, the best non-pharmacological treatment should be carried out after quantifying pain intensity and regular and comprehensive assessment of pain, and if necessary, pharmacological treatment or other coordinated analgesic treatment can be considered. In order to relieve the pain and improve the quality of survival. Joint disorders pain: pain in the preauricular region is mostly seen in temporomandibular joint disorder syndrome, mostly in young people, with joint movement disorders and deep popping and persistent pain in the surrounding muscles when opening or chewing, also accompanied by toothache, headache, earache, etc. If the above symptoms occur, they need psychological, joint function correction, muscle training, correction of bad habits, medication, physical therapy, etc. Fifth, the pain of maxillofacial nerve disorders: often need to take all kinds of painkillers to control. Trigeminal nerve disease is the most common, followed by linguopharyngeal neuralgia, mostly seen in middle-aged and elderly people, more women than men, early in the disease because of its pain and dental disorders caused by similar pain symptoms, not easily distinguished from dental pain, but mostly pain, no pain at night, rarely sustained pain, jumping pain, do not easily remove healthy teeth for early jaw pain. The disease is characterized by a sudden onset and stop like lightning, knife, burning-like and intractable severe pain in the distribution area of the trigeminal nerve of the maxillofacial region, which is a real pain, seriously endangering people’s health and affecting work and life, and its pain degree is the most of all kinds of pain. Trigeminal neuralgia is one of the stubborn diseases of the oral and maxillofacial area, and there is still no absolutely effective treatment method, but in recent years, with the continuous research, some new progress has been made, and the primary trigeminal neuralgia that has been diagnosed after examination can be treated by various conservative treatments such as oral medication, acupuncture, and drug injection in the early stage of the disease, and all of them can get better results, and the remission period ranges from one to several years. The more persistent and refractory trigeminal neuralgia that has not been treated by years of conservative treatment should be treated with nerve-destroying drug nerve stem injections to destroy the nerve that causes the pain in order to achieve pain-free. In addition, treatment can be performed by medical instruments such as radiofrequency thermal coagulation and temperature control, and microbeam compression of the semilunar ganglion. Over the years, our hospital has also achieved good results with trigeminal nerve hypotomy. These treatments can cause numbness in the painful area of the jaw and face, but the treatment is safe and easy. Trigeminal nerve microvascular decompression can preserve the normal nerve sensation in the pain area, and the causative factors of trigeminal neuralgia can be found. r-knife treatment, using a large dose of narrow beam ionizing rays, precisely gathered at the target point, generates huge energy, and produces local focal destruction to achieve the purpose of treating trigeminal nerve. The treatment efficiency is relatively high. The early stage of oral and maxillofacial pain is caused by a variety of reasons, dental diseases, nerve disorders, local inflammation, joint disorders, oral malignant tumors can cause pain, such as the occurrence of pain should be early through the specialist examination to identify the cause of pain, early and correct treatment, never think that toothache is not a disease and delay treatment.