Antifungals are drugs that inhibit or kill fungi and are used to treat fungal infectious diseases. Currently, antifungal drugs on the market mainly work by affecting fungal cell walls and cell membranes. According to the chemical structure is divided into three categories: 1, amphotericin B and mycophenolic antifungal drugs represented by polyenes, antibacterial spectrum is broad but toxic. Amphotericin B is not absorbed through the mucous membrane, the gastrointestinal tract only absorbs a small amount of intravenous administration, is the first choice of systemic deep fungal infections. Mycotoxin because oral skin mucous membrane drugs are not easily absorbed, the treatment of oral mucosa gastrointestinal tract and vaginal Candida infections, more made into tablets, use of water gargling, can be made into an ointment, vaginal suppositories, etc.; 2, pyrroles antifungal drugs, including: imidazoles and triazoles. Imidazoles include: ketoconazole, clotrimazole, miconazole, econazole and sertaconazole. Currently, most of them are topical medications for superficial fungal infections or Candida infections of the skin and mucous membranes. Triazoles including: fluconazole, itraconazole, voriconazole, posaconazole and esaconazole are all used to treat deep fungal infections. The above drugs are prescription drugs, patients should be based on the doctor’s prescription; 3, acrylamines, commonly used in clinical practice is terbinafine, butenafine, naftifine. Used for the local treatment of superficial fungal infections, the theoretical antifungal effect is stronger than ketoconazole. Terbinafine, Butenafine and naftifine cream spray also belong to the OTC class of drugs, safety is good. 4, echinocandins, such as caspofungin and micafungin, etc., such compounds as a non-competitive inhibitor of 1,3-β-D-glucan synthetase, in the inhibition of its biological activity at the same time, does not affect the nucleic acid and mannose biosynthesis. 1,3-β-D-glucan is an important substance to maintain the integrity of the fungal cell wall, but cryptococcus is a very important substance to maintain the integrity of the fungal cell wall. 1,3-β-D-glucan is important for maintaining the integrity of the fungal cell wall, but Cryptococcus is deficient in this substance.1,3-β-D-glucan deficiency leads to increased permeability of the fungal cell wall, cell lysis, and death of the fungus.1,3-β-D-glucan is not present in human cells. Antifungals are prescribed in oral and injectable forms, except for topical medications used for superficial fungal treatment. They are commonly used for more severe superficial fungal or deep fungal infections, and should only be used in outpatient and inpatient settings under the supervision of a physician or pharmacist with a prescription or doctor’s order after the corresponding fungal infection has been confirmed by bacterial culture. Patients should combine the physical condition and economic conditions of the rational choice of drugs, so that the drug can achieve good antibacterial effect and clinical efficacy, but also to reduce their own financial burden. Also adhere to the medication on time, use enough courses of treatment to prevent the recurrence of the disease or the emergence of drug resistance, the use of medication in the process of attention to any physical discomfort should be promptly consulted with the doctor in charge or clinical pharmacist.