The skull is a protective wall for the brain tissue, which protects and supports the brain, but an accident causes a skull defect, which is extremely serious and not only affects the appearance, but also the skull tissue is only connected to the outside world through the scalp after a skull defect, which can lead to greater danger in time. Does severe cranial defect have any effect on health and longevity? Of course, if the skull defect is not repaired in time, the skull will not grow back on its own, and the intracranial pressure and intracranial environment are changed, which will lead to impaired blood circulation and cerebrospinal fluid circulation in the brain, thus inducing a series of neurological dysfunction. In clinical practice, cranial defect will cause headache and dizziness, poor mental activity and irritability, which will affect life and work, and it will be more harmful if it is accidentally bumped. Therefore, once a skull defect occurs, it is important to go to the hospital for skull repair surgery before it is too late. At present, many local hospitals use titanium mesh material for skull repair surgery. Titanium mesh material has slight advantages over previous materials, but there are still some shortcomings, such as postoperative infection, rejection, and even the risk of material exposure. In order to improve this treatment situation, our team used a new polyetheretherketone PEEK material to perform the surgery, which has excellent properties.