Taking progesterone without menstruation does not mean that it is very serious, it may be pregnancy, or the uterine lining is thin, after stopping the drug can not form retreating bleeding, or the method of using the drug and the dose is not appropriate, not stopping the drug or stopping the drug for too short a time, or it may be the menstrual blood outflow is not smooth. Need to consult a doctor in time to take targeted treatment. In addition to adjusting menstruation, do not blindly use drugs on your own. First of all, clear with or without pregnancy, pregnancy state when taking progesterone can play a certain role in protecting the fetus, the endometrium will be in a high dose of progesterone under the action of metaplasia, there will be no menstrual flow. Secondly, low estrogen levels in the body caused by thin endometrium, ovulation and progesterone dose is too low, then the use of progesterone will not necessarily come to menstruation. Need to check gynecological ultrasound and sex hormone levels, the doctor to determine whether it is necessary to change the drug, such as drospirenone ethinyl estradiol tablets, ethinyl estradiol cyproterone tablets and other estrogen hormones, or increase the dosage of progesterone. Estrogenic drugs need to be used in different ways depending on the condition. Progesterone is used to adjust menstruation is generally the second half of the cycle of medication, during the period can not be interrupted, according to the course of treatment to have the effect; if the dosage is smaller or the middle of the medication there is an interruption, there is the possibility of stopping the drug does not come to menstruation, or the use of the drug during the abnormal bleeding. In addition, adhesions in the uterine cavity may cause poor menstrual flow, which may be manifested as lack of menstruation, but often accompanied by lower abdominal discomfort, breast swelling and pain during menstruation, etc., and need to be examined and separated from the adhesions. If menstruation does not occur after taking progesterone, it is necessary to consult a doctor to determine the cause of the disease and then intervene in a timely manner to avoid delaying the disease.