Elderly people with advanced renal failure generally do not need pain relief. Elderly people in the late stage of renal failure body will not appear obvious pain, so generally do not need pain relief, if the kidney disease has developed uremia stage, the elderly will appear serious edema, acidosis, nausea, vomiting, fatigue, and a series of symptoms, at this time need to carry out hemodialysis or peritoneal dialysis to maintain the stability of the internal environment, so as to achieve to improve the quality of life, prolong the life of the purpose of the survival period. The late stage of renal failure generally does not appear obvious pain symptoms, so generally do not need pain relief, and painkillers will have a part of the metabolism through the kidneys, may accelerate the damage to the kidneys, if the patient has a demand for the use of painkillers, to be carried out under the guidance of a professional physician. Elderly people with renal failure, it is recommended to seek medical attention in a timely manner, under the guidance of a physician active treatment.