Patients who are neocoronavirus repositive may be at risk of transmitting the virus. Neocoronavirus repositive positivity is when a person with neocoronavirus infection is cured and initially tests negative for nucleic acid and later tests positive. That is, nucleic acid of novel coronavirus genetic material is found in respiratory specimens. It suggests that the patient may still have novel coronavirus in the respiratory tract, and there may be a risk of transmission of the virus if it is excreted through respiratory droplets. Therefore, the current prevention and control program for novel coronavirus stipulates that patients with novel coronavirus reactivation still need to be isolated and observed until they become negative, and a certain period of home health surveillance is required. This is to prevent the virus present in the respiratory tract of patients with re-positive symptoms from spreading and infecting others through respiratory droplet expulsion from the body. Tip: The “new coronavirus pneumonia” mentioned in this article has been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.