A high coefficient of variation of erythrocyte distribution width is a parameter that measures the uniformity of erythrocyte size, which may be due to pathological hematopoiesis such as erythroid hyperplasia in the bone marrow, or anemia such as iron deficiency anemia.
1. Pathological hematopoiesis: such as myelodysplasia, which to some extent reflects a markedly increased proliferation of the erythrocyte lineage in the bone marrow.
2. Anemia, such as iron deficiency anemia, certain hemolytic anemias, chronic hemorrhagic anemia, etc., can be seen in varying degrees of uneven red blood cell size. Among them, megaloblastic anemia is a disease typically characterized by significant red blood cell size inequality, i.e., high coefficient of variation of red blood cell distribution width.
If high variation coefficient of red blood cell distribution width is found in daily physical examination, it is recommended to go to the hematology department of regular hospitals to avoid delaying the condition.