It is a fashion nowadays to advocate nature and return to nature, and traditional Chinese medicine is becoming more and more popular among patients. Traditional Chinese medicine does have unique efficacy in the treatment of kidney disease, which is indisputable. However, Chinese herbal medicine is not completely free of toxic side effects, once used improperly, “ginseng” can also “kill”. With the massive application of herbal medicine in the medical field, there are more and more reports of kidney damage caused by herbal medicine, which must be taken seriously. Commonly used herbs that can damage kidney function mainly include: Zanthoxylum, Leigong Vine, Hooked, Mountain Cigarette, Fish Gall, Poisonous Mushroom, Cang Er Zi, Mouton, Fang Ji, Ze Di, Arsenicum, Croton, Grass (Chuan) Wu, Strychnine, Cinnabar, Xiong Huang, Light Powder, Goldenseal, Qing Mu Xiang, Aristolochia, Seeking Bone Wind, Cinnabar Lotus, Sinapis, Wang Jiang Nan Zi, Red Ascending Dan, Acacia, Jun Zi, Petunia, Shang Lu, Euphorbia, Gan Sui, Gua Ti. Senna leaves, Aloe vera, Bacopa monniera, Bupleurum, and Sanguisorba root, etc. Some of these drugs can directly damage the renal tubules in the kidney, some can directly damage the glomerulus, and some can cause a decrease in blood flow to the kidney, resulting in kidney function damage, which can cause uremia in serious cases. The nephrotoxicity of these drugs is the greatest with zebrawood, leigongteng, hookwort, mountain cichlid, guanmutong, shandoo root, fish guts and zedoary, the dosage and indications of these drugs should be strictly controlled, patients with kidney disease should avoid using these drugs as much as possible, and patients with chronic nephritis should preferably not use these drugs. Not only that, the long-term use of Chinese patent medicines containing these drugs, such as Zhu Sha An Shen Wan, Gentian Diarrhea Liver Pill, Long Hui Wan, Gynecological Fen Qing Wan, Deafness Wan, Pure Yang Zheng Qi Wan, Da Huang Qing Stomach Wan, Guan Xin Su He Wan, etc., may also cause kidney function damage, therefore, the majority of patients taking Chinese patent medicines must be more careful to find out the ingredients contained in various Chinese patent medicines. When some chronic patients need to take a certain type of Chinese medicine for a long time, they must know the ingredients and the toxic and non-toxic. Also, the medication should be used according to different age, gender and physiological status. Toxic herbs should be used with caution for pregnant women, the elderly and infirm, children and those with allergies. Patients with kidney disease should be as careful as possible when using these drugs and should not use them if they can. The monitoring of liver and kidney function should be strengthened during the medication period, and herbs and pCms with nephrotoxicity should be prohibited for those with kidney failure. In addition to herbal medicines, many commonly used western drugs also have a large nephrotoxicity, must be used with caution, patients with kidney disease is best not to take. Western drugs with obvious nephrotoxicity are mainly the following categories: 1, antibiotics. Among them are aminoglycoside antibiotics. Such as gentamicin, butylamine kanamycin, etc., the most toxic, cephalosporins, sulfonamides also have nephrotoxicity. 2, anti-inflammatory and analgesic drugs. Such as anti-inflammatory pain, ibuprofen, etc. Long-term use of large amounts often cause interstitial lesions of the kidney, the formation of “analgesic nephritis”, and finally develop into kidney failure, and it is difficult to treat. 3. Most anti-cancer drugs. Therefore, patients with renal insufficiency should use chemotherapy drugs with caution. 4.Tachyphylaxis among diuretics. 5.Other ones are cyclocytin, the agents used for CT and other examinations, heavy metals, radiation, etc. Children, the elderly in the use of such drugs is to be sure to be careful, patients suffering from kidney disease is best not to use the above drugs and tests. As the saying goes, medicine has three toxins, it is best to use medicine under the guidance of a doctor, do not take it on your own, blindly.