High fever after chemotherapy can be treated with oral antipyretic drugs such as ibuprofen. In addition to taking simple antipyretic drugs you also need to find out the cause of the high fever and carry out targeted treatment according to the cause. Some patients have a low immune system after chemotherapy, which makes them prone to infections, and if there is an infection, anti-infection treatment should be carried out according to the causative organism. After the infection is controlled, the patient’s body temperature will naturally drop to normal. Patients may have a significant drop in white blood cells and neutrophils after chemotherapy, and in this case they are also prone to high fever, so they need to use granulocyte colony-stimulating factor to raise their white blood cells. Infection is also likely to occur at this time, so prophylactic antibiotics are also needed.