The unevenness of the nail cover of the hand may be due to physiological factors, or it may be considered to be related to pathological factors, such as malnutrition, anemia, fungal infections, psoriasis nails and other diseases. 1.Physiological factors. The nails themselves are not particularly flat and may be high or low. Nails are traumatized and may have a thimble-like bumpy surface. Family members with depressed nails may have uneven nails due to genetic factors. 2. Malnutrition. Usually do not pay attention to nutritional supplementation, long-term partiality and picky eating, weight loss, resulting in a variety of trace elements, nutrients, lack of elements, will have an impact on the growth of nails, resulting in uneven nails. 3. Anemia. Anemia refers to the number of red blood cells in the peripheral blood or hemoglobin content has been significantly lower than normal. If the anemia is prolonged or severe, it will have an impact on the growth of nails, resulting in brittle, thin and uneven nails. 4. Ringworm of the nails. Onychomycosis refers to nail lesions caused by fungi invading the nail plate and nail bed. Patients mainly manifested as nail plate deformation, thickening, discoloration, shedding, and some patients will have the manifestation of uneven nails. 5. Psoriasis nail. Psoriasis has invaded the nails, will affect the nail bed and nail matrix, mainly manifested in the thickening of the nail surface, there are scattered small depressions, look uneven. There may be other factors for uneven nails, so it is recommended to consult a dermatologist for standardized diagnosis and treatment.