Trimethoprim has some therapeutic effect on gastrointestinal peristaltic dysfunction, and can be used in the treatment of gastrointestinal dysfunction. Trimethoprim can act on the smooth muscle of the gastrointestinal tract to regularize the irregular movement of the stomach and improve the obstacle of gastric emptying, and it has a bidirectional effect on the peristalsis and emptying of the stomach, that is to say, it has an inhibitory effect when the gastric motility is hyperactive, and it has a promotional effect when the gastric motility is hypomotor, so that it can regulate gastrointestinal peristaltic dysfunction. Trimethoprim can be used clinically for the treatment of gastrointestinal motility disorders caused by loss of appetite, nausea, vomiting, belching, abdominal distension, abdominal tinnitus, abdominal pain, diarrhea, constipation and other symptoms and intestinal irritability syndrome and other diseases. Therefore, when peristaltic dysfunction occurs in patients with gastrointestinal dysfunction, trimethoprim can be taken for treatment. However, Trimebutine may cause constipation, diarrhea, bowel sounds, numbness in the mouth, dizziness, headache and other adverse reactions when taking, which usually disappear gradually after stopping the drug. For the existence of organic or occupational lesions in the digestive tract of patients, children, the elderly, pregnant women and lactating women should be, etc. should be used with caution. Patients with gastrointestinal dysfunction disorders are advised to seek timely medical attention for professional treatment. Drugs must be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition. If there is a serious adverse reaction when taking the drug, you should stop taking the drug and consult a doctor in time.