Substantial intrahepatic masses are common diseases: primary liver cancer, metastatic liver cancer, hepatic hemangioma, focal nodular hyperplasia and so on. 1. Primary hepatocellular carcinoma: malignant tumor originated from hepatocytes or intrahepatic bile duct cells, with more common causes such as hepatitis, alcohol and aflatoxin. Patients mainly present with pain in liver area, abdominal distension, poor appetite, fatigue, emaciation, progressive hepatomegaly or epigastric mass. Color ultrasound shows substantial mass in the liver, CT and MRI can assist diagnosis. CT and MRI can assist the diagnosis. Puncture pathology can assist the diagnosis. 2. Metastatic hepatocellular carcinoma: metastatic hepatocellular carcinoma can be formed through transferring with blood or lymphatic fluid or directly infiltrating the liver, and common metastases originate from the stomach, pancreas, esophagus, ovary, intestines and so on. Color ultrasound shows substantial masses in the liver, and CT and MRI can assist in diagnosis. 3. Hepatic hemangioma: it is mostly seen in cavernous hemangioma in clinic, which is usually caused by congenital, due to the abnormal development of hepatic blood vessels in the process of embryonic development, which causes the abnormal proliferation of vascular endothelial cells to form hepatic hemangioma. Color ultrasound often shows substantial intrahepatic mass, but enhanced CT can help differential diagnosis, which shows fast in and slow out. 4. Focal nodular hyperplasia: it is a benign lesion, which refers to the nodular hyperplasia of hepatocytes, usually without obvious symptoms, such as compression can be manifested as high bilirubin, jaundice, pain in liver area. Color ultrasound can show substantial nodules or masses in the liver, and puncture biopsy can confirm the diagnosis. If there is a substantial intrahepatic mass, it is recommended to go to the hospital in time.