The main difference between humoral immunity and cellular immunity lies in the different immune cells, different substances, different targets and different reaction times. 1. Different immune cells: humoral immunity is mainly carried out by B cells, while cellular immunity is carried out by T cells. 2. Different action substances: the action substances of humoral immunity are mainly specific antibodies, while the action substances of cellular immunity are mainly effector T cells and lymphokines. 3. Different objects: the object of humoral immunity is the antigen that invades the human body environment, while the object of cellular immunity is the host cell that carries the antigen. 4. Reaction time is different: humoral immunity requires the second invasion of antigen to cause an immune response, while cellular immunity can play an immune role in the first invasion of antigen. Humoral immunity and cellular immunity complement each other to protect the organism, and these tissues should be protected.