Coladin transdermal patch is more effective for vocal tics, and other medications include thiabendazole and haloperidol. Tourette’s syndrome is a common neuropsychiatric disorder in children or adolescents, including motor tics and vocal tics, which can cause psychological damage or affect social functioning. Thiamphenicol and haloperidol are dopamine receptor blockers, but drowsiness and extrapyramidal reactions can occur, and the side effects are more pronounced compared to coladin transdermal patch. Coladin belongs to non-psychotropic drugs, low side effects, high safety, widely used in children with tic disorders. Coladin transdermal patch belongs to the adrenergic alpha agonist, non-psychotropic drugs, expert consensus suggests that it is the first-line drugs for the treatment of tic disorders, and the effect is relatively good for vocal tics. Tourette’s syndrome should be based on the child’s symptoms to choose different drugs, it is recommended to use medication under the guidance of a doctor to avoid adverse consequences or delays in the condition.