In clinical work, more and more patients consult about AIDS and suspect that they have AIDS. In fact, the vast majority of them are AIDS-phobic rather than AIDS-phobic. AIDS-phobia, also called AIDS-phobia, is a psychological disorder with a strong fear of AIDS, accompanied by a variety of psychological symptoms and behavioral abnormalities such as anxiety, depression, obsessive-compulsive, and hypochondriacal. Patients suspect that they are infected with HIV, or they are very afraid of being infected with HIV and have obsessive-compulsive disorder such as cleanliness, showing mental depression, mood changes, severe insomnia, indifference to things around them, weight loss, swollen lymph nodes, fever, skin rash, mouth sores, abnormal tongue coating and general discomfort. They may even suspect that every object may carry HIV, and worry that people around them will infect them with HIV or that they will infect their family members with HIV. In severe cases, patients may show some extreme abnormal behaviors, such as fear of going to “dangerous” situations or public places, fear of contact with “suspicious people” or even anyone, fear of wounds, fear of blood, and in severe cases, fear of going out all day long and fear of meeting people. When they think of or see the word “AIDS” and AIDS-related reports, or even hear the word “AIDS”, they will be nervous, panic, short of breath, and fearful. Measures: These patients have a common feature, that is, they have a recent history of high-risk sexual behavior, tattoos, dental repair, blood collection (including the patient’s own perception of poor blood collection sterilization) and other experiences, patients often have a certain understanding of the disease, and the most critical is the personality problem, these patients tend to be introverted or psychologically suggestive, because it is a psychological disorder, therefore, the most critical is to solve the psychological problem. Therefore, the most critical thing is to solve the psychological problems, through consulting professional doctors, repeated negative tests to completely rest assured, really understand the knowledge of AIDS, more interaction with others, or go out for outdoor activities to divert attention, if the patient is particularly serious, it is necessary to see a psychiatrist or even use some appropriate drug intervention. From our doctors’ point of view, it is our duty to strengthen the publicity of AIDS knowledge, especially to popularize the basic knowledge of AIDS and AIDS prevention and treatment is an effective measure to help patients to eliminate AIDS phobia.