Mastocytosis is a common disease among young and middle-aged women and is closely related to endocrine dysfunction, and is essentially a disorder of the breast structure caused by physiological hyperplasia and incomplete regeneration. Clinically, it is often divided into different types according to different periods, and its performance is also slightly different. 1. Breast pain: 21 to 25 years old, with a history of several weeks or months, averaging 3 months. The pathology is characterized by mild or severe hyperplasia of the ductal vesicles and lobular interstitium, and mild dilatation of the small ducts. The prominent manifestation is breast pain. 2. Lobular hyperplasia type: 26~30 years old, disease duration about one year. The hypertrophic glands with poorly defined boundaries can be palpated with tenderness, mostly accompanied by premenstrual distension and menstrual disorders. The pathology is characterized by an increase in lobular hyperplasia with clear boundaries and cellular infiltration inside and outside the lobules, and the degree of lesions varies with the menstrual cycle. 3, fibroadenosis type: 31-40 years old, the course of the disease is about 1~2 years. The prominent manifestation is breast lumps, which can be found as lamellar masses with poorly defined borders, or round nodules with unsmooth surface, hard texture and varying sizes. The pathology is hyperplasia of both the main stroma and interstitium, with dilated ducts and may be accompanied by verrucous nodules. 4.Fibrosis type: 41~45 years old, disease duration about 2 years. A few patients have premenstrual breast pain. On examination, an irregular, ill-defined, unsmooth, tough mass with no tenderness can be found. The pathology is seen as interstitial fibrosis, lobular atrophy or disappearance, and deformation of the glandular ducts. 5.Cystic disease type: 46~55 years old, the course of the disease is about 2~3 years. It often presents as a single or several scattered cysts, 1-2 cm or even 3-4 cm in diameter, with little or no premenstrual breast distension. Pathology is seen as ducts and alveoli that are dilated to varying degrees, forming cyst-like changes of varying sizes. It is generally said that although breast pain is a physiological change, it is also an early lesion of mastocytosis, while the cystic type is a more advanced lesion with the possibility of cancer. The cancer problem: The literature reports that the cancer rate of mastocytosis is 2%~4%. However, some scholars believe that the combination of clinical, histological and long-term follow-up is necessary to determine whether there is cancer. Generally speaking, those with atypical hyperplasia on biopsy should be considered as precancerous lesions. Therefore, puncture or surgical biopsy should be performed as early as possible for those who appear suspicious during the follow-up. It is concluded that breast hyperplasia may be one of the risk factors for the development of breast cancer, and it is difficult to distinguish this disease from breast cancer in the early stage, so it is important to strengthen the follow-up observation. Light: breast pain is vague or scattering pain, unilateral or bilateral breast lumps, single small lumps, or granular and small in extent, or stripes, soft and confined to one quadrant. 2, medium-sized: breast pain is dull pain or pain and tenderness, swelling pain is obvious, the lump is large, or in the shape of a sheet or disk, involving both breasts, but the range in two quadrants. 3.Heavy: breast pain is cramping or stabbing pain, obvious tenderness, large lumps, multiple cystic nodules, involving both breasts, and the range is more than two quadrants.