Hand numbness and pain may be caused by keeping the same posture for a long time or arm pressure for a long time, or it may be caused by certain diseases, such as nerve entrapment, cervical spondylosis, diabetic peripheral neuropathy and so on. 1. Keeping the same posture for a long time or arm pressure for a long time will make the vascular nerve pressure for a long time, poor blood circulation leads to local ischemia and hypoxia, causing numbness and pain in the hand. 2. Nerve compression: the median nerve, ulnar nerve and other peripheral tissues are compressed by the nerve compression or tumor compression will lead to hand numbness and pain. 3. Cervical spondylosis: neurogenic cervical spondylosis will make the compressed cervical nerve innervation area of radiating pain, numbness, often manifested as numbness and pain in the upper limbs and hands. 4. Diabetic peripheral neuropathy: diabetic patients due to metabolic disorders, vascular injury, neurofactor deficiency may lead to peripheral nerve lesions, causing numbness and pain. If there is severe hand numbness and pain affecting sleep, it is recommended to go to the regular hospital in a timely manner, under the guidance of the doctor to improve the relevant examination and follow the doctor’s instructions and active treatment.