If creatinine is high and cystatin C is normal it is possible that the creatinine is elevated for physiologic reasons. Creatinine can be affected by diet, exercise, infection and other factors, such as eating too much meat, performing strenuous physical exercise, etc. can lead to a transient increase in creatinine, which may return to normal after the removal of the triggering factors in general. Cystatin C is mainly used to monitor glomerular filtration function and has fewer influencing factors. It is not affected by biological factors such as age, body weight and metabolic level, and is not affected by lipemia, jaundice and hemolyzed specimens, and it is now recommended that cystatin C should replace the traditional urea nitrogen and creatinine as the first choice of indicator to judge glomerular function. Therefore, a slightly higher creatinine and normal cystatin C may occur with the above mentioned interfering factors. If creatinine is high and cystatin C is normal, it is recommended to consult regular hospitals for standardized treatment under the guidance of physicians.