The drugs applied to vulvodynia should be used according to the clinician’s judgment and according to the patient’s specific situation, such as diabetic patients, after the etiology is well treated, even without the need for topical application of drugs. Commonly used drugs are mainly: 1, antibiotic ointment coating, such as Bactroban, chrysomycin ointment, comfrey oil, etc., with anti-inflammatory, insecticidal effect; 2, Phellodendron lotion or coating solution, Ketorol, Clotrimazole cream, etc., the effect is better; 3, pay attention to vulvar hygiene, keep the vulva clean and dry.