Itching and skin thickening of female vulva may be caused by the destruction of micro-ecological environment in the vagina and the decrease of immunity, which is more common clinically in chronic simple moss of vulva and non-specific vulvovaginitis, etc. It needs to be treated according to different causes. 1. Chronic simple moss of vulva: the specific cause is still unclear, which may be related to the decrease of local content of alpha of vitamin A receptor, mainly manifested as itching of vulva, scratching because of It is difficult to tolerate and scratch, which may further aggravate the lesions, and the symptoms of skin thickening and pigmentation appear over time, and the skin texture is obvious, which may be accompanied by scratches, chaps and ulcers. It is recommended that the local application of fluorethyl acetate cream to control the itching, after the symptoms are relieved to switch to hydrocortisone cream maintenance, skin thickening requires a longer period of time to improve or return to normal, for serious symptoms or the use of drugs after the ineffective, you can use focused ultrasound, laser and other physical therapy; 2, non-specific vulvovaginitis: due to vulva stimulated by menstrual blood, vaginal secretions, do not pay attention to clean, or fecal fistula The patient can be stimulated by pollution for a long time, which can cause non-specific inflammatory reactions, or prolonged skin friction, local humidity, poor permeability can also cause. The main manifestations are itching, pain, burning sensation of vulvar skin, visible skin thickening, roughness, cracking, and even moss-like changes. It is recommended to use povidone iodine solution or potassium permanganate bath, and then apply antibiotic drugs for treatment, such as erythromycin ointment, etc.; 3, other causes: such as drug allergies, if the vulva local use of relevant drugs to treat diseases, and their own allergic body, may be stimulated by local allergic substances and lead to itching, through scratching can lead to thickening of the skin, it is recommended to take loratadine tablets and other drugs as prescribed by the doctor This can help relieve the symptoms. In addition to treating the causes of vulvar itching and skin thickening, women need to keep their skin clean and dry, not eat spicy, greasy and other irritating foods, and avoid intercourse before the symptoms are relieved.