Neuroblastoma in children can be caused by a variety of factors such as congenital factors, environmental factors, genetic factors, and gene mutations. 1. Congenital factors: congenital factors may cause neuroblastoma in children, but the specific pathogenesis is not very clear, and it may be caused by malignant changes of the embryonic tissue residues. 2. Environmental factors: if the pregnant mother is infected with certain bacteria or viruses during pregnancy, or takes certain drugs, or comes into contact with chemicals for a long time, or smokes and drinks alcohol for a long time, all of them may be the reasons for the child to get neuroblastoma. 3. Genetic factors: neuroblastoma may also have some relationship with genetic factors, if the family members have tumors or malignant tumors, the chances of children getting neuroblastoma will be higher. 4. Genetic mutation: If the fetus has chromosome short-arm deletion, rearrangement, chromatin abnormality, etc. during development, it may cause neuroblastoma in children, and about 1% to 22% of neuroblastoma is caused by genetic mutation. About 1% to 22% of neuroblastoma is caused by gene mutation. Neuroblastoma in children may also be caused by some other factors, parents are advised to bring their children to the hospital to receive professional examination and treatment in time, so as to avoid delaying the condition.