Exercise after staying up late may lead to sudden death, but generally occurs on the basis of organic heart disease. For patients with coronary heart disease, exercise after staying up late often causes acute myocardial ischemia, leading to angina pectoris, myocardial infarction, and disturbances in the electrical activity of myocardial cells, and malignant arrhythmias, and even sudden death. For some patients with heritable hypertrophic obstructive cardiomyopathy, exercise after staying up late often results in acute ischemic events, leading to the occurrence of sudden death. For anyone, especially patients with underlying disease, overexertion is not recommended, and exercise after staying up late often prompts extreme events, so it needs to be circumvented. In addition, attention should be paid to regular checkups at the hospital for primary and secondary prevention of the disease.