Whether or not to apply antibiotics for fever in children is determined by the cause of the fever. If the child has a fever due to cold, cephalosporin antibiotics should not be applied. If the child has a viral infection, the fever caused in the early stage of the viral infection, i.e. the viremia stage, should be treated symptomatically, with the addition of antiviral drugs at most. If the child’s fever is related to a bacterial infection, and the fever and inflammation are caused by a bacterial infection, the application of antibiotics should only be considered based on the child’s unremitting high fever, high blood counts, and high C-reactive protein, and confirming that there is indeed clinical evidence of a bacterial infection. The application of antibiotics must be bacterial infection, cold, mycoplasma infection, viral infection should not choose cephalosporin antibiotics.