Clostridium tetani is an anaerobic bacterium that is widespread in the natural environment and is susceptible to infection in humans and animals, with deeper, contaminated wounds being more at risk. Glass cuts usually require a tetanus shot, but it is not possible to generalize, as glass cuts can be left unvaccinated if they are shallow and not at risk of infection. Tetanus is an acute infectious toxic disease caused by Clostridium tetani. Tetanus toxin can cause persistent tonicity and paroxysmal spasms of the skeletal muscles throughout the body, resulting in ankylosis, a bitter smile, inability to move on their own, asphyxiation, respiratory failure, and until death, with an untreated case fatality rate of nearly 100%. Tetanus shot is tetanus antitoxin, its specific antibody can neutralize tetanus toxin, used for prevention and treatment of tetanus. Glass cuts are more likely to be infected with tetanus and require careful treatment of the wound, thorough debridement and disinfection, and usually an early tetanus vaccination within 24 hours. However, if the glass cut wound is shallow with no abnormal active bleeding and there is no risk of infection, tetanus vaccine may not be given. In case of glass cuts, it is necessary to go to a regular hospital in time for standardized treatment in order to reduce the occurrence of various infections.