1, long-acting sulfonylureas are prone to hypoglycemia, including glibenclamide, etc. Generally speaking, people over 60 years old, it is best not to use again. Secondly, the drug must be combined with diet, can not eat the drug, and then do not pay attention, delay eating, or do strenuous exercise, is also prone to cause the occurrence of hypoglycemia. In this case, you can consider short-acting sulfonylureas, biguanides, thiazolidinediones, etc. These drugs have a lower risk of hypoglycemia and can be considered for application. 2. For patients with insulin application, the injection of regular insulin or premixed insulin before meals can easily lead to hypoglycemia before the next meal, so it needs to be noted that after applying insulin, you should eat in about 15 to 20 minutes to avoid not eating food, or delaying eating for too long. Ultra-short-acting insulins can reduce the chance of hypoglycemia. Long-acting insulin analogues such as glargine insulin or detergent insulin have a calmer and longer duration of action, which reduces the occurrence of nighttime hypoglycemia more than traditional intermediate-acting insulins. Therefore, sugar lovers who have frequent hypoglycemia should have chocolate and other foods on them, especially those who are on insulin.