The hand is a very important organ of human beings, due to the exposure of the area, it is easy to cause damage, and after the burns are mainly deep burns, when the surgical repair, due to the limited source of human full-thickness skin, can not meet the needs of large area burns patients for the skin source. After years of clinical research, we finally developed a new biological material to replace the human full-thickness dermis source – that is, decellularized allogeneic dermis (Jie subdermis). This material adopts the patented technology of decellularization, which is treated by biological and biochemical methods to remove the epidermis and decellularize the skin, preserving the morphology, three-dimensional structure and composition of the extracellular matrix. It retains the intact basement membrane, which can guide the growth and differentiation of new epithelial cells, creating a good foundation for the viability of autologous epidermis and the connection between epidermis and dermis. The composite graft of decellularized allogeneic dermis and autologous epidermis has the characteristics of toughness, abrasion resistance, inhibition of granulation growth, and prevention of scar formation. In addition, it can promote the connection between epidermis and dermis and the proliferation and differentiation and maturation of keratin-forming cells to restore the inherent barrier function of the wound after healing. Because of the good histocompatibility of decellularized allogeneic dermis, it has low rejection reaction and can survive for a long time after transplantation on the trauma. Surgical cases The composite graft was performed on 18 patients, among which 15 patients with extensive burns and insufficient autologous dermis sources were transplanted with decellularized allogeneic dermis (Jie subdermis) and autologous epidermis; 3 patients were transplanted with artificial dermis and autologous epidermis. After the incrustation of the sub-operative wound, the wound was covered with decellularized allogeneic dermis to promote the growth of wound granulation. 3 to 5 days after the wound was fresh, bleeding actively, without infection, the wound was closed with decellularized allogeneic dermis and autologous bladed thick skin graft, packed and wrapped with pressure, and the stitches were removed in 10 to 12 days. 3 cases of artificial dermis transplantation required the sponge layer to be tightly attached to the wound, and the edges were sutured to the periwound skin, wrapped and fixed, and 10 to The red granules were observed to grow under the silicone film in 10 to 12 days after surgery, and the superficial silicone film was removed and the autologous thick skin was transplanted on the granules. After the operation, the postoperative effect of the composite graft of decellularized allogeneic dermis and autologous skin is smooth, lightly contracted and wear-resistant. It is less prone to blistering, and has the effect of inhibiting scar formation and promoting wound healing, which greatly improves the quality of wound healing. The color and texture of the skin at the site of the composite skin graft is closer to normal. Caution To avoid infection of the patient’s wound after transplantation, the scab must be cut very thoroughly during the surgery, so that no necrotic tissue remains and the wound base must be fresh to ensure blood flow. The patient’s trauma after scab cutting is carefully cleaned with hydrogen peroxide and saline, and the decellularized allograft dermis is cleaned with gentamicin saline and wet dressing to further reduce the chance of infection. When implanting decellularized allograft dermis, it is important to ensure that the rough side is downward to ensure the important role played by the basement membrane for wound healing, that the skin pieces are spreading, that there are no folds, and that the mesh is unfolded, but that the mesh is not stretched wide. When transplanting the thick skin slice, the base, decellularized allograft dermis and thick skin slice should be closely connected to avoid accumulation of air and blood under the skin slice, and the edges should be firmly sutured. In order to avoid sliding of the thick skin slice, the outer layer of the skin slice can be covered with petroleum jelly and fixed with a sterile bandage, and then wrapped with a sterile dressing with pressure. Avoid violence when wrapping, so that the dressing is evenly stressed. The composite graft of decellularized allogeneic dermis and autologous blade-thick skin slice ensures the recovery of appearance and function after healing of the skin slice, and at the same time reduces the scar production after healing of the donor area.