Low total protein and albumin refer to abnormalities in the synthetic function of the liver and systemic nutritional status. Amino acids absorbed in the gastrointestinal tract can be re-synthesized in the liver as albumin, while globulin is an important marker reflecting the inflammatory response of the body’s immune system, and the sum of albumin and globulin is called total protein. Reasons affecting protein values include the following: 1. Liver disease: when liver function is affected, such as viral hepatitis, alcoholic cirrhosis, drug-induced liver injury, liver abscess, and other diseases, the synthesizing function of the liver can be affected, leading to a decrease in albumin; 2. Inadequate nutrient intake: patients who consume only greens and tofu and do not consume enough animal meats can result in a lower level of ingested protein; 3, Overconsumption: For example, patients with hyperthyroidism, diabetes mellitus and renal failure have high metabolism and consume too much protein, and when the consumption exceeds the intake, the protein level can be lower than normal. Therefore, if patients find that the total protein and albumin are reduced, they should promptly investigate the causes leading to the reduction of protein and carry out symptomatic treatment, so as to restore the normal level.