Follicular lymphoma grade 2 stage 4 is relatively serious. Follicular lymphoma is divided into a total of three grades. Grade 1 is predominantly micronucleated schwannomas with a relatively uniform follicular size pattern. Grade 2 is a mixture of goblet cells and large cells, which can be either large goblet cells, or anaplastic cells. Tertiary is predominantly large cells whose cellular composition can be either macropinocytosis or anaplasmacytosis. As the disease progresses, the follicular changes become progressively more blurred and may eventually become diffuse. Each stage can be divided into four stages: stage 1 is usually limited invasion of a single extranodal organ or site; stage 2 may present with limited invasion of two or more lymph nodes on the same side of the diaphragm, or a single extranodal organ or site on the same side of the diaphragm; stage 3 involves lymph node invasion on both sides of the diaphragm, which may be accompanied by splenic invasion; and stage 4 often presents with metastases to the liver or bone marrow. Follicular lymphoma stage 2 or 4 is characterized by a mixture of small nucleated schistocytes and large cells, and metastasis to the liver or bone marrow, which is relatively more serious. It is recommended to go to the hospital in time and standardize the treatment with the help of doctors.