Aspirin and isosorbide nitrate can be taken together for the treatment of coronary heart disease. Coronary artery disease is a serious narrowing of the coronary arteries, the need for oral antiplatelet drugs to prevent platelet aggregation, aspirin belongs to the commonly used drugs. Patients with angina need to take oral dilation of coronary arteries, commonly used drugs are isosorbide nitrate. Aspirin and isosorbide nitrate belong to the basic drugs for the treatment of patients with coronary artery disease, there is no contraindication to the simultaneous use of the two drugs, can be used at the same time. Aspirin’s main role is to inhibit platelet aggregation, adverse reactions have stomach pain, nausea, abdominal pain, some patients can occur gastrointestinal bleeding, allergic to drug components, aspirin first over asthma, active ulcers, active bleeding of patients prohibited. Isosorbide nitrate mainly dilates blood vessels, adverse reactions include headache, dizziness, palpitations, etc., patients allergic to drug components are prohibited. Need to pay attention to the use of drugs need to be under the guidance of a professional physician, not unauthorized use of drugs.