For hepatitis B patients with red dots on the palms of their hands, two conditions should be treated differently: in the first case, the patient has red dots on the hands, but they are limited to one side, with itching or other discomfort. In this case, the rash is mostly considered to be caused by allergies or other skin diseases. In this case, the patient only needs to pay attention to continue to observe, to be identified after the cause of the disease, for the treatment of skin disease can be. In addition, patients with allergies can also consider taking loratadine and calcium gluconate in appropriate amounts for anti-allergy treatment; in the second case, if there are widespread red spots all over the body, and accompanied by local petechiae, patients should further consider blood tests, liver function and coagulation function. This is because in patients with underlying liver disease, the amount of prothrombin synthesized by the liver decreases due to poor liver function, which can trigger further subcutaneous bleeding and bleeding tendencies in other areas. If a patient has coagulation disorders due to poor liver function, the patient needs to be treated with active liver protection and, if necessary, plasma input for further support. However, if the patient also has thrombocytopenia, the possibility of hypersplenism should be considered. If hypersplenism is present, the patient needs to be actively considered for portal flow dissection if necessary. The third condition is to pay attention to exclude the possibility of hepatic palms, which mainly manifest as red spots and plaques between the size of the fissures, mostly seen in patients with cirrhosis, but also in some patients with abnormal estrogen metabolism.