Chromosomal abnormalities are a common cause of recurrent spontaneous. In early pregnancy spontaneous abortion, the incidence of karyotype abnormalities is as high as 50-60%. Since the report of chromosomal abnormalities associated with recurrent spontaneous miscarriage in 1962, chromosomal abnormalities in miscarrying couples have attracted widespread medical attention and have been studied more extensively. Chromosomal examination of both couples and miscarriage products has also been included as a routine test. The incidence of karyotypic abnormalities found in couples with chromosomal examinations ranges from 3-10%. Common abnormalities are: ectopic (44%), chimeric (48%), and missing or in place (8%). There is no effective treatment for miscarriage due to carryover of chromosomal abnormalities, and only prenatal genetic counseling and diagnosis can be performed. For autosomal balanced translocations and non-homozygous Loboson ectopic carriers, there is a theoretical chance of delivering normal karyotype and carrier babies, and prenatal testing should be done for these couples to ensure a normal baby. Couples who are not medically advised to have children should not be forced to do so. Another situation is when both couples are chromosomally normal, but chromosomal abnormalities occur during gamete formation and embryo development. For example, age older than 35 years and aging eggs are prone to chromosomal non-separation, resulting in chromosomal abnormalities. Semen abnormalities such as large-headed malformed sperm are mostly diploid and form polyploid embryos after fertilization leading to miscarriage. Adverse environment such as toxic chemicals, radiation, high temperature, etc.