According to the Neococcal Pneumonia Protocol, children with Neococcal Pneumonia presenting with a rash need to be differentiated from Kawasaki Disease. Children with C.N.C.P. may present with high fever, low blood pressure, rash, and dyspnea, which are similar to the characteristics of Kawasaki disease. Kawasaki disease is a systemic vasculitis disease, which may be manifested by persistent fever, enlarged lymph nodes, rash in multiple areas of the body, and sore throat and diarrhea. The occurrence of Kawasaki disease is not directly related to neococcal pneumonia, but the symptoms are similar, and Kawasaki disease needs to be excluded when a rash is present in neococcal pneumonia. In rare cases, children infected with C. neoformans may develop a multi-system inflammatory syndrome with symptoms similar to those of Kawasaki disease. In order to avoid a poor prognosis, children infected with C. neoformans need to seek medical attention in a timely manner, and should be informed of any discomfort that occurs during the course of treatment and follow the doctor’s instructions. Tips] In this article, “new coronary pneumonia, new coronary virus pneumonia” has been renamed to “new coronary virus infection” on December 26, 2022, as announced by the National Health Commission.