The normal value of AST is 0-40 U/L, and the normal value of ALT is 0-40 U/L.High ALT and AST indexes indicate impaired liver function. Factors causing high ALT and AST may include physiologic factors, viral hepatitis, cirrhosis, fatty liver, alcoholic liver disease, and even liver cancer. Treatments include lifestyle modification, antiviral drugs and surgery.
1. Physiological factors: Generally, the causes of transient liver cell damage are strenuous exercise, alcoholism, overwork and other factors, which will lead to a transient increase in ALT and AST, and after eliminating these factors, most of the time, the aminotransferases will recover by themselves.
2. Viral hepatitis: The cause of this disease is that hepatitis B and C viruses destroy liver cells, resulting in the release of aminotransferases into the bloodstream. Treatment of hepatitis requires the use of antiviral drugs such as entecavir. At the same time, liver-protecting drugs such as glycyrrhizic acid preparations and bicyclic alcohol can be used appropriately.
3. Fatty liver: It is due to the excessive accumulation of fat in liver cells which damages the liver cells and causes the release of transaminases into the blood. Generally speaking, fatty liver does not need medication, but dietary control and exercise are enough.
4. Alcoholic Liver Disease: Alcoholism leads to liver damage and the release of aminotransferases into the blood. The first step is to stop drinking and can be treated with hepatoprotective drugs such as polyene phosphatidylcholine and reduced glutathione.
In addition, cirrhosis, liver cancer, etc. may also cause elevation of ALT and AST. It is recommended to go to the hospital in time to clarify the cause of the disease and treat the symptoms.