The 70-year-old man with nephrotic syndrome is not obvious effect of medication, it is recommended to do renal puncture examination, according to the type of pathology to choose a reasonable drug treatment program. Clinical nephrotic syndrome includes more pathological types, the treatment effect is not obvious, such as oral hormonal drugs symptoms do not improve, there is still more proteinuria, comply with medical advice without contraindications can be carried out renal puncture biopsy, according to the type of pathology to choose a reasonable treatment program. Different pathologic types have different treatment effects, such as membranous nephropathy can consider using hormones combined with immunosuppressants for treatment, such as prednisone, cyclophosphamide, etc., and can also choose rituximab for treatment. Other types can be considered to be treated with hormone alone or combined with immunosuppressant. It is recommended that patients with nephrotic syndrome go to the hospital in time, complete the examination under the guidance of the doctor, clarify the treatment plan and follow the doctor’s instructions. Usually pay attention to rest, prevent infection, monitor blood pressure, regular review.