High blood sugar may cause heartburn. Patients with high blood sugar may develop diabetic cardiovascular lesions when they have high blood sugar for a long period of time, which may cause heart pain, and may also be caused by physiological factors, or chest wall diseases and other reasons. 1. Diabetic cardiovascular lesions: when high blood glucose patients with high blood glucose for a long time may appear cardiac microvascular lesions and myocardial metabolic disorders,, may cause heart pain. 2. Physiological factors: overwork, late at night, mental stress, emotional fluctuations, strenuous exercise may lead to high blood sugar patients with heartburn symptoms. 3. Chest wall disease: herpes zoster, acute dermatitis, subcutaneous cellulitis, rib fracture, chest contusion and other diseases, if the inflammation is spread to the pleura, can also lead to high blood sugar patients with symptoms of heartburn. High blood sugar patients with symptoms of heart pain, should go to the regular hospital in time, in order to clarify the cause of heart pain and give professional treatment, do not abuse drugs, so as not to delay the condition.