Megakaryocyte maturation disorder may be caused by idiopathic thrombocytopenic purpura, hypersplenism and megaloblastic anemia, etc. Different causes of the disease are treated differently, and the treatment includes medication. 1. Idiopathic thrombocytopenic purpura: the first choice of drug glucocorticosteroids, such as prednisone acetate, dexamethasone, etc. Glucocorticosteroids can reduce the production of related antibodies, and the destruction of platelets by the spleen to increase the density of blood vessels and reduce bleeding. 2. Hypersplenism: generally use erythropoietin subcutaneous injection, if necessary, through the intravenous infusion of red blood cells, such as drug treatment, the condition has not been effectively relieved, it is recommended to perform splenectomy, to reduce the destruction of platelets site. 3. Megaloblastic anemia: It is recommended to take folic acid or vitamin B₁₂ under doctor’s guidance. If megakaryocyte maturation disorder is found, it is recommended to consult a doctor in time to find out the cause of the disease and take medication early under the doctor’s guidance.